Description

5-Amino-1MQ 50mg (60 Capsules)
5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N
methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and
is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in
nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism,
thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1).
SIRT1 is also known as the “longevity gene” because of its role in reducing the risk of diabetes,
obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney
disease, liver disease, neurodegeneration, and cancer. Research in mice given 5-amino-1MQ
showed a 7% reduction in body mass over 10 days without any changes in food intake,
compared to controls. Research has shown that decreasing NNMT may help shrink fat cells and
reduce the size of fat deposits.
5-amino-1MQ (5-amino-1methylquinolinium) an analogue of methylquinolinium, is a short
peptide inhibitor of cytosolic nicotinamide N-methyltransferase (NNMT) The NNMT enzyme
has been linked to both obesity and type 2 diabetes and is known to play a role in energy
homeostasis within the cell. Inhibiting NNMT leads to significant weight loss, decreased fat
mass and fat cell (adipocyte) size, and lower plasma cholesterol and glucose levels. 5-amino
1MQ and other methylquinolinium derivatives are under active investigation as potential
treatments for obesity and diabetes. It also appears that inhibition of NNMT can activate stem
cells and improve regenerative capacity in skeletal muscle.