Description

MK-677, is a orally bio-active, selective agonist of the ghrelin receptor. Research shows that MK
677 increases the natural secretion of growth hormone (GH) and insulin-like growth factor 1
(IGF-1), but does not affect cortisol levels. It is being researched as a possible treatment for GH
deficiency, muscle and bone wasting, appetite stimulation and Alzheimer’s disease. MK-677
research in mice, appeared to prevent the onset of AD, even in genetically predisposed mice, as
long as it was started before significant amyloid beta accumulation. MK-677 research has also
shown exceptionally promising benefits in improving sleep quality.
MK-677, also known as lbutamoren and Oratrope, is a potent, orally active, selective
agonist of the ghrelin receptor This makes it a growth hormone secretagogue and ghrelin
mimetic. It is not a ghrelin analogue, however, as it is not a peptide and therefore shares no
structural similarities to ghrelin. Research shows that MK-677 increases the secretion of
growth hormone (GH) and insulin-like growth factor 1 (IGF-1), but does not affect cortisol
levels. This means that MK-677 activates the GH axis and therefore promotes an increase in
lean body mass. It is under investigation as a treatment for growth hormone deficiency,
muscle and bone wasting, and appetite stimulation. MK-677 is valued for its long half-life and
excellent oral bioavailability. Research in human’s shows that IGF-1 levels remain elevated for
up to 24 hours after a single dose of MK-677.